Article 4221

Title of the article

A pharmacotherapy of atrial fibrillation in subclinical thyrotoxicosis 

Authors

Ruslan F. Rakhmatullov, Assistant, sub-department of internal diseases, Medical Institute, Penza State University (40 Krasnaya street, Penza, Russia), E-mail: pgu-vb2004@mail.ru
Lyudmila V. Mel'nikova, Doctor of medical sciences, associate professor, professor of the sub-department of family medicine and polyclinic therapy, Russian Medical Academy of Continuous Professional Education (building 1, 2/1 Barrikadnaya street, Moscow, Russia), E-mail: lumel2408@yandex.ru
Inessa Ya. Moiseeva, Doctor of medical sciences, professor, head of the sub-department of general and clinical pharmacology, Medical Institute, Penza State University (40 Krasnaya street, Penza, Russia), E-mail: moiseeva_pharm@mail.ru
Fagim K. Rakhmatullov, Doctor of medical sciences, professor, head of the sub-department of internal diseases, Medical Institute, Penza State University (40 Krasnaya street, Penza, Russia), E-mail: pgu-vb2004@mail.ru 

Index UDK

616.12-008.318+616.441 

DOI

10.21685/2072-3032-2021-2-4 

Abstract

Background. Pharmacological therapy of atrial fibrillation (AF) in subclinical dysfunction of the thyroid – is the most important problem of modern clinical medicine. The purpose of the study is to conduct a complex assessment of electrophysiological indicators of the heart and lipid profile in patients with subclinical thyrotoxicosis and paroxysmal AF during antiarrhythmic and thyrostatic therapy. Pharmacological therapy of atrial fibrillation (AF) in subclinical dysfunction of the thyroid is the most important problem of modern clinical medicine.
Materials and methods. 126 patients with frequent paroxysms of AF with subclinical thyrotoxicosis were examined. All patients underwent ECG control, EP study, assessment of thyroid hormones level and lipid profile. Therapy included treatment with bisoprolol, sotalol, thiamazole and their combinations.
Results. Electrophysiological predictors of AF in subclinical thyrotoxicosis were identified. It was found that euthyroid status does not reduce a number of spontaneous paroxysms of AF. High antiarrhythmic efficacy of combined use of bisoprolol with thiamazole and sotalol with thiamazole has been proven. 

Key words

subclinical thyrotoxicosis, atrial fibrillation, thiamazole, bisoprolol, sotalol 

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References

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Дата создания: 24.08.2021 14:54
Дата обновления: 27.08.2021 12:38